Hypertension an important global health challenge is the prevalent cause of cardiovascular disease. Natural products are emerging as new therapeutic tools in the management of hypertension due to side effects and the patient’s adherence of the existing treatments. In present study we investigated the antihypertensive effect of the Euphorbia hirta in deoxycorticosterone acetate (DOCA)–salt model of hypertension in rats. Administration of Euphorbia hirta extract (PJ- 100 mg/kg and 300 mg/kg; p.o.) for 4 weeks in DOCA treated rats significantly (P<0.05) reduced the mean arterial blood pressure and vascular reactivity changes to various catecholamines. E. hirta treatment significantly (P<0.05) decreased the levels of thiobarbituric acid reactive substances (TBARS); while enzyme activity of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH) in kidney tissue were significantly increased. Results of the present work suggest that Euphorbia hirta extract has an antihypertensive action in unilateral nephrectomized DOCA-salt hypertensive rats and could be possible starting point for treatment of hypertension with increased patient adherence.
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